The Clift in San Francisco is in Union Square, and is within short distance of several park amusements. Customers of the guesthouse can pay a visit Nob Hill, Chinatown, Fisherman's Wharf, and other regions. Travelers able to also utilize the town's cable auto system to go through more of the city. The Clift San Francisco is 12 miles from the San Francisco International Airport, and it is just a short ride from the airport in Oakland. Visitors at the inn will find plenty of forms of social transport, including buses and taxis, which able to take them to other districts of the town. Some park amusements are even within short distance.

The Hotel Clift in San Francisco features 372 rooms for guests. Visitors at the guesthouse will find the apartments feature sleigh beds, desks, televisions, satellite radio, mini bars, CD players, and more. I-net access is obtainable for a fee.

Constructed in 1913, the inn features an Italian Renaissance styled exterior. Clients at the Clift San Francisco Hotel will find an onsite gymnasium that is open 24-hrs a day, in addition to an onsite restaurant called Asia de Cuba that serves a range of cuisine.