The E.F. Lane Hotel is a peculiar forty-room hotel situated in the Heart of Cheshire County and the Monadnock Region. The E.F. Lane Hotel is the unmatched hotel on Main Street in charming Downtown Keene New Hampshire. The E.F. Lane is housed in a construction with long standing traditions in Main Street s E. F. Lane Block and has uniquely styled lodgings to establish a superbly cozy stay.