The San Francesco Hotel Assisi is one of the hotels in Assisi that is exactly around the corner from the Basilica di San Francesco, sitting just thirty m from the landmark. It's also within five minutes' stroll of the Piazza del Comune and the Basilica di Santa Chiara. The San Francesco Hotel Assisi is approximately ten kilometers from the airport, and five minutes' drive from the railway station.

There are 44 apartments at the San Francesco Hotel Assisi, all with air conditioning. Suites comprise wi-fi Internet, satellite TV, minibar, and en apartment bathroom with hair dryer. Most suites face the Basilica.

The San Francesco Hotel Assisi is a reconstructed 15th century building with modern inside spaces. This restaurant can offer meals throughout the day, focusing on Umbrian specialties and seasonal dishes with local ingredients. A complimentary morning breakfast cafeteria is offered. The rooftop verandah is open most of the year and proposes vistas of the rural area and the church spires together with cocktails. Parking zone is available on a limited basis for visitors.